PENGARUH VARIASI KONSENTRASI PVP K30 (FILM FORMING) TERHADAP MUTU FISIK ORAL FAST DISSOLVING FILM SALBUTAMOL SULFATE


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Abstraksi ABSTRACT
THE EFFECT OF VARIATION OF PVP K30 CONCENTRATION (FILM
FORMING) ON THE PHYSICAL QUALITY OF ORAL FAST
DISSOLVING FILM SALBUTAMOL SULFATE
Oktavia Tyo Angreny, Deny Budi Legowo
Oral Fast Dissolving Film (OFDF) is a drug with a new preparation which,
when placed in the mouth, disintegrates rapidly to release the drug. Medicines like
this will provide greater advantages over other preparations, namely that they are
flexible and not brittle, can be administered without drinking water and have the
potential to increase patient compliance in taking medication. OFDF preparations
are composed of main components called film forming agents, one of which is
Hydroxy Proply Methyl Cellulose (HPMC). HPMC forms a transparent, strong
and flexible film, but has a slightly brittle nature and a slightly rough surface.
Several additives are often mixed to get the desired film properties, including
Polyvinyl Pyrolidone k30 (PVP K30). This OFDF preparation uses the active
ingredient Salbutamol Sulfate with various formulations, with the addition of PVP
K30 concentrations of 0,5%, 1% and 1,5% to obtain good physical quality results.
The method used in the manufacture of OFDF Salbutamol Sulfate is the Solvent
Casting method. Purpose: This study aims to be experimental used to determine
the effect of variations in the concentration of PVP K30 as film forming on the
physical quality of making Oral Fast Dissolving Film.
Conclusion: Data collection was carried out on physical characteristics
including variations in weight, thickness, tensile strength, pH of preparation,
swelling power and assay. The results obtained are the thickness of the film 0.2
mm, - 0.4 mm, weight variation 0.050 grams - 0.064 grams, tensile strength 3.583
- 3.966 grams / mm2, pH 5.7 - 6.1, expansion power 120.478% - 122.381%,
uniformity content 85.0295% - 99.6803%. The result is that the concentration
increases, the greater the elasticity of the oral fast dissolving film.
Keywords: Oral Fast Dissolving Film (OFDF), Polyvinyl Pyrolidone k30 (PVP
K30), Hydroxy Proply Methyl Cellulose (HPMC), Salbutamol Sulfate, Solvent
Casting method.
Pengarang Oktavia Tyo Angreny - Personal Name (Pengarang)
Universitas Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
Tahun 2021
Tempat Krian



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