UJI AKTIVITAS TONIKUM EKSTRAK ETANOL DAUN KEJIBELING (Strobilanthes crispus) PADA MENCIT JANTAN (Mus muscullus)


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Abstraksi TONIC ACTIVITY TEST OF KEJIBELING
(Strobilanthes crispus) LEAF ETHANOL EXTRACT
in MICE MOUES (Mus muscullus)
Nuraida Choirun Nisak, Panji Suci Ratih., S. Farm., M.Farm
Pharmacy Pharmacology Division, Mitra Sehat Mandiri Pharmacy Academy
Sidoarjo 61262, INDONESIA
ABSTRACT
Kejibeling plant (Strabilanthes crispus) is a wild herbaceous plant with
many health benefits. The kelibeling plant contains chemical substances, including:
potassium, sodium, calcium, silicic acid, alkaloids, saponins, flavonoids, and
polyphenols. The purpose of the study was to determine the activity of the ethanol
extract of kejibeling leaves (Strobilanthes cripus) against tonic and the effective dose
in male mice (Mus muscullus) compared to positive control (caffeine 100 mg/kg BW)
and negative control (CMC-Na 0.5%). The research method, True experimental with
pretest posttest approach with control group, tested using 15 male mice, with
different doses of ethanol extract of kejibeling leaves at doses
of 100mg/kgBW, 200mg/kgBW, and 400mg/kgBW while the control was positive
(100 mg/kgBW caffeine). and negative control (CMC-Na0.5%). Data analysis was
carried out by observing the length of time for swimming resistance from the start of
the male mice being put into the aquarium until the male mice showed fatigue marked
by no reaction from all four legs, bent body position, and the head was on the surface
of the water for 4-7 seconds, after which they were given treatment. each group, then
the male mice were swimming again. The results showed that Kejibeling
(Strobilanthes cripus) leaf ethanol extract had a good tonic effect at a dose
of 400mg/kg BW with an average swimming time of 885 seconds (14 minutes 45
seconds), a dose of 200mg/kgBW with an average swimming time of 718 seconds.
seconds (11 minutes 58 seconds), a dose of 100mg/kgBW with an average swimming
time of 409 seconds (8 minutes 16 seconds) in male mice. The most effective dose of
Kejibeling (Strobilanthes cripus) leaf ethanol extract was 400mg kgBW in male mice.
The positive control treatment (caffeine 100 mg K-BW) obtained results with an
average swimming length of 1442 seconds (24 minutes 2 seconds) and negative
control (CMC-Na 0.5%) with an average swimming length of 227 seconds: (03
minute 47 seconds). In conclusion, the results of the One Way Anova test analysis
have a significant value <0.05 compared to positive control and negative control
indicating differences between treatment groups. Kejibeling (Strobilanthes cripus)
leaf ethanol extract at a dose of 400 mg Kg BW was proven to have a tonic effect
Keywords, Kejibeling Leaf, tonic, male mice, CMC-Na 0.5% and
Caffeine 100 mg KgBB
Pengarang Nuraida Choirun Nisak - Personal Name (Pengarang)
Universitas Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
Tahun 2021
Tempat Krian



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