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<title><![CDATA[KARYA TULIS ILMIAH UJI AKTIVITAS TONIKUM EKSTRAK DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT JANTAN (Mus musculus)]]></title>
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<namePart>Denisa Widyaningsih</namePart>
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<namePart>Panji Ratih Suci, S.Farm., M.Farm</namePart>
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<namePart>Apt. Elly Purwati, S.Si., M.Farm-Klin</namePart>
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<namePart>Panji Ratih Suci, S.Farm., M.Farm</namePart>
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<namePart>Sih Wahyuni Raharjeng, M.Si</namePart>
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<place><placeTerm type="text"><![CDATA[Krian]]></placeTerm></place>
<publisher><![CDATA[Akademi Farmasi Mitra Sehat Mandiri Sidoarjo]]></publisher>
<dateIssued><![CDATA[2022]]></dateIssued>
<issuance><![CDATA[monographic]]></issuance>
<edition><![CDATA[Published]]></edition>
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<languageTerm type="text"><![CDATA[Indonesia]]></languageTerm>
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<itemTypeTerm type="text"><![CDATA[KARYA TULIS ILMIAH]]></itemTypeTerm>
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<note>ABSTRAK
Pola kerja aktivitas yang semakin meningkat membutuhkan tenaga yang lebih banyak, sehingga dapat menyebabkan kelelahan, karena itu kebutuhan akan obat penambah stamina menjadi meningkat karena mereka menginginkan segera pulihanya tenaga mereka dalam waktu sesingkat mungkin agar mereka bisa meneruskan aktivitas sehari-hari dengan stamina yang lebih segar dan bugar. Tonikum suatu bahan atau bahan campuran untuk memperkuat tubuh atau tambahan tenaga atau energi pada tubuh, Daun melinjo (Gnetum gnemon L.) Serta buahnya mengandung alkaloid, tanin, saponin, dan flavonoid. Flavonoid berpotensi sebagai antioksidan dan mempunyai aktivitas sebagai anti bakteri, anti inflamasi, anti alergi dan anti trombosi, golongan flavonoid dan terpenoid dimana senyawa tersebut diduga dapat menimbulkan efek tonikum. Penelitian ini adalah penelitian eksperimental dengan desain pretest-posttest control group design. Sampel diambil secara acak. Mencit sebanyak 25 ekor dibagi menjadi 5 kelompok. Percobaan uji efek tonikum dilakukan menggunakan metode daya tahan berenang mencit sebelum dan sesudah pemberian larutan uji yang diberikan peroral. Kelompok I diberi CMC-Na (kontrol negatif), kelompok II diberi kafein dosis 100mg/kg BB (kontrol positif), kelompok III, IV dan V diberi ekstrak etanol daun melinjo (14 mg/kgBB, 28 mg/kgBB, 42 mg/kgBB).

ABSTRACT
The increasing pattern of work activities requires more energy, so that it can cause fatigue, therefore the need for stamina-enhancing drugs increases because they want to recover their energy as soon as possible so that they can continue their daily activities with fresher stamina. and fit. Tonic is an ingredient or mixture of ingredients to strengthen the body or additional energy or energy in the body, melinjo leaves (Gnetum gnemon L.) and the fruit contain alkaloids, tannins, saponins, and flavonoids. Flavonoids have potential as antioxidants and have activity as anti-bacterial, anti-inflammatory, anti-allergic and anti-thrombotic, flavonoid and terpenoid groups where these compounds are thought to have a tonic effect. This research is an experimental study with a pretest-posttest control group design. Samples were taken randomly. As many as 25 mice were divided into 5 groups. The tonic effect test experiment was carried out using the mice's swimming endurance method before and after the test solution was given orally. Group I was given CMC-Na (negative control), group II was given caffeine at a dose of 100mg/kg BW (positive control), Groups III, IV and V were given ethanol extract of melinjo leaves (14 mg/kgBW, 28 mg/kgBW, 42 mg/kgBW).</note>
<subject authority=""><topic><![CDATA[Uji Aktivitas Tonikum]]></topic></subject>
<subject authority=""><topic><![CDATA[Ekstrak Daun Melinjo]]></topic></subject>
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