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<title><![CDATA[KARYA TULIS ILMIAH UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN  MARKISA KUNING (Passiflora edulis) PADA Escherichia coli]]></title>
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<namePart>Latifatul Fauziyah</namePart>
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<namePart>Panji Ratih Suci, S.Farm., M.Farm</namePart>
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<namePart>Dr. Cikra Ikhda N.H.S, S.Farm., Apt</namePart>
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<namePart>Panji Ratih Suci, S.Farm., M.Farm</namePart>
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<namePart>Sih Wahyuni Raharjeng, M.Si</namePart>
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<publisher><![CDATA[Akademi Farmasi Mitra Sehat Mandiri Sidoarjo]]></publisher>
<dateIssued><![CDATA[2021]]></dateIssued>
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<languageTerm type="text"><![CDATA[Indonesia]]></languageTerm>
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<itemTypeTerm type="text"><![CDATA[KARYA TULIS ILMIAH]]></itemTypeTerm>
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<note>ABSTRAK
Diare adalah suatu kondisi dimana tubuh kehilangan sebagian besar cairan dan elektrolit yang disebabkan karena buang air besar sebanyak tiga kali atau lebih dalam sehari dengan konsistensi cair yang disebabkan oleh bakteri Escherichia coli. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri dari ekstrak etanol daun markisa kuning (Passiflora edulis) untuk menghambat pertumbuhan bakteri Escherichia coli. Metode penelitian ini menggunakan metode True Eksperimental. Penelitian ini menguji terkait uji aktivitas antibakteri ekatrk etanol daun markisa kuning (Passiflora edulis) dengan konsentrasi 10%, 20%, dan 30% dengan metode disc diffusion (difusi cakram) dengan 3 kali replikasi. Hasil penelitian menunjukkan bahwa ekstrak etanol daun markisa kuning (Passiflora edulis) memiliki aktivitas untuk menghambat pertumbuhan bakteri Escherichia coli dengan diameter zona hambat pada konsentrasi 10% yaitu 3,85 mm (lemah), konsentrasi 20% yaitu 6,62 mm (sedang) dan pada konsentrasi 30% yaitu 11,69 mm (kuat), dibandingkan dengan kontrol positif (Amoxicillin) yaitu 14,55 mm (kuat). Semakin besar konsentrasi ekstrak etanol daun markisa kuning (Passiflora edulis) maka semakin besar nilai diameter zona hambat namun besarnya masih lebih kecil dibandingkan dengan kontrol positif. Data ini didukung analisis data dengan oneway ANOVA didapatkan nilai sig <0,05 yakni 0,000 yang berarti terdapat perbedaan daya aktivitas antibakteri yang signifikan dari setiap konsentrasi, kontrol positif (Amoxicillin) dan kontrol negatif (Aquadest).

ABSTRACT
Diarrhea is a condition in which the body loses most of the fluids and electrolytes caused by defecating three or more times a day with a liquid consistency caused by the Escherichia coli bacteria. The research was aims to know the antibacterial activity of ethanol extract of passion fruit leaves (Passiflora edulis) against Escherichia coli bacteria. This research uses method of True Experimental. This research tested the antibacterial effects ethanol extract of passion fruit leaves (Passiflora edulis) with concentrations of 10%, 20%, and 30% using the disc diffusion method with 3 replications. The results showed that the ethanol extract of yellow passion fruit (Passiflora edulis) leaves had activity to inhibit the growth of Escherichia coli bacteria with an inhibition zone diameter of 10% of 3.85 mm (weak), 20% of 6.62 mm (moderate) and at a concentration 30% of 11.69 mm (strong), compared to the positive control (Amoxicillin) of 14.55 mm (strong). The greater concentration ethanol extract of yellow passion fruit (Passiflora edulis) leaves, the greater the diameter of the inhibition zone, but still smaller than the positive control. This data is supported by data analysis using one-way ANOVA, the value of sig <0.05 is 0.000, which means that there is a significant difference in antibacterial activity for each concentration, positive control (Amoxicillin) and negative control (Aquadest).</note>
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