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Acne is a chronic inflammatory disease in the polysebaseus unit that often occurs especially in adolescents and young adults characterized by blackheads, papules, pustules, nodules, and cysts. The purpose of this study was to determine the profile of treatment and the effectiveness of zinc medication in acne sufferers at the “X” beauty clinic. The research design used a prospective non-experimental descriptive approach which was carried out in February -April 2020 with a sample of all patients who were treated with a diagnosis of acne and were given zinc drug therapy. Based on a sample of 125 prescription data, according to the sex of female patients as many as 48 people (74%) and 17 men -17 people (27%), while according to age the most experienced acne was in women aged 18 years, the percentage was obtained (16.6 %) and male aged 19 years (35.2%). From the results of this study, it was found that the drug profile that was often used during treatment for additional drug therapy as anti-inflammatory diazink 20 mg tablets (38.70%).