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<title><![CDATA[VARIASI LAMANYA PENCAMPURAN AKHIR TERHADAP MUTU FISIKORAL FAST DISSOLVING TABLETS DOMPERIDONE BASE]]></title>
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<note>According  to  (Gupta  A,  2010).Oral  fast  dissolving  tablets  (OFDT)  are tablet preparations that when placed on the tongue will disintegrate in less than 60 seconds.  In  the  manufacture  of  tablets  required  binder,  filler,  destroyer,  lubricant and coloring agent, among which the destroyer.  Prostitute material is intended to guarantee  the  destruction  of  the  tablet  in  less  than  60  seconds.  The  active substance  will  then  dissolve  or  be  dispersed  in  the  presence  of  saliva,  then swallowed  by  the  patient,  and  the  drug  is  absorbed  as  usual.  A  small  amount  of saliva  is  expected  to  be  sufficient  to  allow  tablet  disentegration.  Therefore,  no water  is  needed  to  swallow  water  (Koseki  et  al.,  2008).  This  will  facilitate  and improve patient compliance in using the drug.In making tablets the mixing process is a critical parameter that needs to be reviewed, it is hoped that in a few minutes the mixing process will become more homogeneous.  According  to  (Source:  Handbook  of  pharmaceutical  Excipients  p. 404). The addition of magnesium stearath in mixing can affect the results, this is due  to  the  formation  of  hydrophobes.  Magnesium  stearath  can  form  a  thin  layer that  can  affect  the  bonding  properties  of  these  solid  particles  because  the  role  of magnesium stearath causes granule flow time to get faster, angle ofrest less, and the longer time to disintegrate the tablet.</note>
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