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UJI MUTU FISIK ORAL FAST DISSOLVING FILM DOMPERIDONE BASE TERHADAP VARIASI KONSENTRASI HPMC SEBAGAI FIL FORMINGTEST PHYSICAL QUALITY ORAL FAST DISSOLVING FILM DOMPERIDONE BASE AGAINST VARIATIONS IN THE CONCENTRATION OF HPMC AS FILM FORMINGMega Aditya Devi1, Deny Budi Legowo2Akademi Farmasi Mitra Sehat Mandiri SidoarjoEmail : megaadityadevi26@gmail.comIntisari Oral Fast Dissolving Film (OFDF) merupakan suatu bentuk sediaan baru yang ketika diletakkan di dalam mulut dapat terdisintegrasi dengan cepat untuk melepaskan obat, terlarut dan terdispersi di dalam saliva umumnya kurang dari 1 menit. Sediaan OFDF tersunsun dari komponen utama yang disebut film forming agentsalah satunya Hydroxy Proply Methly Cellulose (HPMC). Pembuatan sediaan OFDF ini menggunakan bahan aktif domperidone base dengan berbagai macam formulasi, dengan penambahan konsentrasi HPMC 600 mg ; 1200 mg ; 1800 mg untuk memperoleh hasil mutu fisik yang baik. Metode yang digunakan dalam pembuatan OFDF domperidone base ini adalah metodesolid dispersion extrusion. Pengumpulan data dilakukan terhadap karakteristik fisik meliputi ketebalan, variasi bobot, daya mengembang, kekuata tarik, pH sediaan, dan kadar. Hasil yang diperoleh ketebalan film 0,69 mm -1 mm, variasi bobot 0,056 gram –0,070 gram, daya mengembang 102,6 % -126,3 %, kekuatan tarik 1,517-3,107 gram/mm2, pH 5,7 –6,1, keseragaman kandungan 72,74 % -88,34 %. Hasil yang di dapat semakin bertambah konsentrasi maka semakin kecil elastisitas oral fast dissolving film.Kata kunci :oral fast dissolving film (OFDF), hydroxyl proply methly celullose (HPMC) dan carboxy methyl cellulose (CMC-Na), domperidone base, metode solid dispersion extrusion.Abstrak Oral Fast Dissolving Film (OFDF) is a new dosage form that when placed in the mouth can be quickly disintegrating to release the drug, dissolved and dispersed in the saliva generally less than 1 minute. OFDF dosage is sunsun from the main component called film forming Agent, one of which is Hydroxy Proply Methly Cellulose (HPMC). The preparation of these OFDF preparations use the active ingredient domperidone Base with a wide range of formulations, with the addition of concentrations of HPMC 600 mg; 1200 mg; 1800 mg to obtain good physical quality results. The method used in the manufacture OFDF Domperidone Base is a solid dispersion extrusion method.Data collection is done against physical characteristics including thickness, variation of weights, inflated power, tensile strength, dosage of dosage, content and dissolution. Result obtained film thickness 0.69 mm-1 mm, Weight variation 0.056 gram –0.070 gram, inflated power 102.6% -126.3%, tensile strength1,517-3,107 gram/mm2, pH 5.7 –6.1, Content uniformity 72.74% -88.34%. The results can increase inconcentration, the smallerthe elasticity of oral fast dissolving film.Keywords:oral fast dissolving film (OFDF), hydroxyl proply methly celullose (HPMC) and dan carboxy methyl cellulose (CMC-Na), Domperidone base, method solid dispersion extrusion.