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Wiwin Dwi Rahmawati Pengarang Apt. Deny Budi Legowo, S.Farm., M.Farm Dosen Pembimbing 1 Apt. Andri Priyoherianto, S.Farm., M.Si Ketua Penguji Dr. Cikra Ikhda N.H.S, S.Farm., Apt Penguji 1 Apt. Deny Budi Legowo, S.Farm., M.Farm Penguji 2

Domperidoneis a medicine to relieve nausea and vomiting. The most common dosage used by the community is tablets, the disadvantage of which is that the patient has difficulty swallowing. In overcoming these disadvantages, tablets are formed in OFDT (Oral Fast Dissolving Tablets) preparations. The disintegrant is an important component in the tablet crush process. One type of disintegrant that can be used is crosprovidone. To minimize disintegrant production costs combined with starch oryzae.The purpose of this study was to obtain the most effective, fast absorption, and minimizing production costs. The method used is experimental. Using a domperidone base sample. Three different formulations were tested. The maximum wavelength is 287 nm. The concentrations used in the domperidone base calibration are 5 ppm, 10 ppm, 15 ppm, 20 ppm, 25 ppm, 30 ppm. The results obtained were tested using SPSS One Way Anova.The results obtained in this study are the best formulation, namely the third formulation crosprovidone: amylumoryzae (1%: 3%) because it has the fastest disintegration time and meets the requirements of OFDT tablets with an average of 10.33 seconds. Meanwhile, the first formula with 2% crospovidone crusher resulted in an average disintegration time of 31.11 seconds. And for the second formulation yields an average disintegration time of 171.66 seconds, this is due to the lack of concentration on the crushing agent.