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Mega Aditya Devi Pengarang Apt. Deny Budi Legowo, S.Farm., M.Farm Dosen Pembimbing 1 Dr. Iswandi, S.Si, M.Farm., Apt Ketua Penguji Apt. Elly Purwati, S.Si., M.Farm-Klin Penguji 1 Apt. Deny Budi Legowo, S.Farm., M.Farm Penguji 2

Oral Fast Dissolving Film (OFDF) is a new dosage form that when placed in the mouth can be quickly disintegrating to release the drug, dissolved and dispersed in the saliva generally less than 1 minute. Such drugs will provide greater benefits than other preparations, which are flexible and not brittle forms, can be administered without the help of drinking water, and potentially improve patient adherence in the use of drugs. OFDF dosage is sunsun from the main component called film forming Agent, one of which is Hydroxy Proply Methly Cellulose (HPMC). The preparation of these OFDF preparations use the active ingredient domperidone Base with a wide range of formulations, with the addition of concentrations of HPMC 600 mg; 1200 mg; 1800 mg to obtain good physical quality results. The method used in the manufacture OFDF Domperidone Base is a solid dispersion extrusion method.Purpose:The researchaims to experimentally used to determine the influence of the concentration variations of HPMC as a film forming againts the physical quality oral fast dissolving film. Conclusion:Data collection is done against physical characteristics including thickness, variation of weights, inflated power, tensile strength, dosage of dosage, content and dissolution. Result obtained film thickness 0.69 mm-1 mm, Weight variation 0.056 gram –0.070 gram, inflated power 102.6% -126.3%, tensile strength1,517-3,107 gram/mm2, pH 5.7 –6.1, Content uniformity 72.74% -88.34%. The results can increase in concentration, the smaller the elasticity of oral fast dissolving film.